Rx00244 - Tretinoin


Name:
Tretinoin
Rx ID:
Rx00244
Validation Level:
Phenomic Similarity:
0.526
Reference ID:
DB00755
Primary Indications:
French-American-British acute promyelocytic leukemia classification M3; acne vulgaris; flat warts; psoriasis; ichthyosis congenita; icthyosis vulgaris; lamellar icthyosis; keratosis palmaris et plantaris; epidermolytic hyperkeratosis; senile comedones; senile keratosis; keratosis follicularis; Darier's disease; basal cell carcinomas; photodamage
Orphan Indications:
No annotated orphan indications.
Rare Indications:
Squamous metaplasia of the ocular surface epithelia; mucous deficiency; keratinization; acute leukemia; chronic leukemia; T-cell, non-Hodgkin's lymphoma
Common Indications:
Acute promyelocytic leukemia
Drug Interactions:
Atazanavir; Carbamazepine; Celecoxib; Demeclocycline; Desogestrel; Doxycycline; Drospirenone; Eltrombopag; Ethinyl Estradiol; Ethynodiol; ...
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Food Interactions:
No annotated food interactions in DrugBank.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00244
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
senile comedones mucous deficiency 1143 16665 29525 9.373 0 0.0
acne vulgaris mucous deficiency 1143 16665 29525 9.373 0 0.0
French-American-British acute promyelocytic leukemia classification M3 acute promyelocytic leukemia 941 941 941 4287.911 0 0.0
psoriasis mucous deficiency 545 9320 29525 7.991 1.85E-280 5.94e-277
flat warts mucous deficiency 260 2463 29525 14.426 3.54E-193 1.14e-189
keratosis palmaris et plantaris mucous deficiency 186 1831 29525 13.883 3.99E-136 1.28e-132
keratosis follicularis mucous deficiency 186 2739 29525 9.28 9.20E-108 2.96e-104
Darier's disease mucous deficiency 186 2739 29525 9.28 9.20E-108 2.96e-104
basal cell carcinomas T-cell, non-Hodgkin's lymphoma 141 6075 6716 13.944 1.61E-105 5.17e-102
senile keratosis mucous deficiency 278 8310 29525 4.572 7.44E-90 2.39e-86
photodamage mucous deficiency 60 3124 29525 2.625 1.02E-10 3.26e-07

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
PSORIASIS ACUTE LEUKEMIA 4.07e-27 3807, ABCB1, ABCC1, ABCF1, ABCG2, ABHD16A, ACE, ADAM33, AGT, ALOX12, ALOX15, APOE, BAG6, BAK1, BDNF, C2, C6orf15, CARD8, CCL2, CCR1, CCR2, CCR4, CCR5, CD14, CD28, CD40, CFB, COL11A2, CRP, CTLA4, CX3CR1, CYP1A1, CYP1A2, CYP2C19, DAXX, DDR1, DEFB1, DHFR, EDN1, EGF, ERCC2, FCGR2A, FCGR3A, FCGR3B, FGF1, FGF2, FOXP3, FPGS, GGH, GPX1, GSTM1, GSTP1, GSTT1, HFE, HLA-A, HLA-B, HLA-C, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-E, HLA-G, HSPA1A, HSPA1B, HSPA1L, IER3, IFNG, IKZF3, IL10, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL15, IL17A, IL17F, IL19, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL2, IL21, IL22, IL22RA2, IL23R, IL2RA, IL4, IL4R, IL6, IL6R, IL8, IRAK1, IRF1, IRF5, JAK2, KIF5A, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DP1, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DP1, KIR3DS1, KLRC4, LAG3, LEP, LST1, LTA, MBL2, MDC1, MDM2, MEFV, MICA, MIF, MIR146A, MMP2, MTHFR, NAT2, NFKB1, NFKBIA, NFKBIL1, NLRP1, NOD2, NOS2, NOS3, NOTCH2, NOTCH4, NQO1, NR3C1, PON1, PTPN22, RAD50, REL, REV3L, RFC1, RUNX1, SLC22A4, SLC6A4, SOCS1, SOD2, STAT2, STAT3, STAT4, STK19, TAP1, TAP2, TGFB1, TLR10, TLR2, TLR4, TLR9, TNF, TNFAIP3, TNFRSF10A, TNFRSF11A, TNFRSF1A, TNFRSF1B, TNFRSF9, TNIP1, TP53, TRAF1, TRIM27, TSC1, TYK2, TYMS, VDR, VEGFA
BASAL CELL CARCINOMAS ACUTE LEUKEMIA 2.89e-18 ACE, BRAF, BRCA1, BRCA2, CAT, CCND1, CD3EAP, CDKN1A, CDKN2A, CDKN2B, CLPTM1L, CTLA4, CTNNB1, CYP1A1, CYP2D6, EGFR, ERCC1, ERCC2, ERCC6, FAS, FASLG, FGFR2, GLI1, GPX1, GSTA4, GSTM1, GSTM3, GSTO2, GSTP1, GSTT1, HFE, HLA-DRB1, IFNG, IL10, IL12A, IL1A, IL1B, IL1RN, IL2, IL4, IL6, IL8, IRF4, LIG4, MDM2, MICA, MIR146A, MMP3, MMP8, MMP9, MTHFR, NBN, PTCH1, PTGS2, RNASEL, TERT, TLR4, TNF, TP53, TP53BP1, VDR, XPA, XPC, XRCC1, XRCC2, XRCC3

Chemical, Pharmacological and Biological Annotations


ATC Code:
D10AD01; D10AD51; L01XX14; D10BA01 D10AD04;
Brands:
Aberel (Janssen); Aberela (Janssen); Airol (Pierre Fabre Dermo); Dermairol (Roche); Eudyna (Zydus); Kétrel (Bailleul); Retisol-A (Stiefel); Sotret (Ranbaxy Laboratories Inc.); Stieva-A (Stiefel); Vitinoin
Categories:
Antineoplastic Agents; Keratolytic Agents
ChEBI ID:
15367
PubChem ID:
444795
KEGG Drug ID:
D00094
SMILE:
CC(C=CC1=C(C)CCCC1(C)C)=CC=CC(C)=CC(O)=O
InChI:
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
Classification:
Kingdom:
Organic Compounds
Superclass:
Lipids
Class:
Prenol Lipids
Subclass:
Retinoids
Indication:
For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin condit...
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Pharmacodynamics:
Tretinoin, also known as all-<i>trans</i>-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and ar...
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Description:
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used ...
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Mechanism:
Tretinoin binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is associated with...
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Adsorption, Distribution, Metab