Rx00250 - Valproic Acid

Name:
Valproic Acid
Rx ID:
Rx00250
Validation Level:
Phenomic Similarity:
0.599
Reference ID:
DB00313
Primary Indications:
Familial adenomatous polyposis; Fragile X syndrome
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Bipolar disorder; acute mania; psychosis; migraine headaches; complex partial seizures; complex absence seizures; absence seizures
Drug Interactions:
Acetylsalicylic acid; Asenapine; Carbamazepine; Clarithromycin; Eltrombopag; Erythromycin; Felbamate; Glycerol Phenylbutyrate; Lacosamide; Lamotrigine; ...
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Food Interactions:
Avoid alcohol. Do not take with milk. Take with food.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00250
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
familial adenomatous polyposis bipolar disorder 1280 17923 34537 8.344 0 0.0

Chemical, Pharmacological and Biological Annotations


ATC Code:
N03AG01
Brands:
Convulex; Depakine; Deprakine; Encorate; Epilim; Valcote; Valparin
Categories:
Enzyme Inhibitors; Anticonvulsants; Antimanic Agents; GABA Agents
ChEBI ID:
9926
PubChem ID:
3121
KEGG Drug ID:
D00399
SMILE:
CCCC(CCC)C(O)=O
InChI:
1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
Classification:
Kingdom:
Organic Compounds
Superclass:
Organonitrogen Compounds
Class:
Amines
Subclass:
Polyamines
Indication:
For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and th...
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Pharmacodynamics:
The relationship between plasma concentration and clinical response is not well documented. One contributing factor is the nonlinear, concentration dependent protein binding of valproate which affects the clearance of the drug. Thus, monito...
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Description:
Valproic acid, supplied as the sodium salt valproate semisodium or divalproex sodium, is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It ma...
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Mechanism:
Valproic Acid dissociates to the valproate ion in the gastrointestinal tract and then binds to and inhibits GABA transaminase. The drug's anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (G...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Non-substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Ready biodegradable
Rat acute toxicity:
1.8543 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

Knowledge Mapping to Biomedical and Healthcare Ontologies

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Term MatchType Ontology ID
COMPLEX PARTIAL SEIZURES PREF ADO AlzheimerOntology#CPS
FRAGILE X SYNDROME PREF ICD9CM 759.83
MIGRAINE HEADACHES SYN EFO EFO_0003821
BIPOLAR DISORDER SYN HP HP_0007302
PSYCHOSIS PREF CRISP 2484-8182
VALPROIC ACID PREF NCIT Thesaurus.owl#C29536
ACUTE MANIA PREF MEDDRA 10000852
COMPLEX PREF BIOMODELS PATO#PATO_0001504
FAMILIAL ADENOMATOUS POLYPOSIS PREF MEDDRA 10059327
ABSENCE SEIZURES SYN ONTOAD OntoAD#C0014553

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Contact Us:
 Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.
Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org
© 2016 Joel T Dudley Laboratory Research | © 2016 Icahn School of Medicine at Mount Sinai